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Long-term weight regain: In a landmark study, participants regained two-thirds of the weight lost within one year of stopping semaglutide

The absence of a control group limits causal inference, and the modest sample size reduces the precision of estimates

Without specific safety data, most clinicians would exercise considerable caution before prescribing such a combination, and many would advise against it entirely in favour of optimising single-agent therapy first

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October 29, 2025: Report Says 12% of Americans Have Used Ozempic or Another GLP-1 Drug About 12% of Americans have used Ozempic or another GLP-1 drug, many of whom have experienced severe side effects